ویروسشناسی پزشکی
ارائه کننده مطالب کاربردی کلیدی و پایه برای محققین حوزههای پزشکی و علوم پایه پزشکیویروسشناسی پزشکی
ارائه کننده مطالب کاربردی کلیدی و پایه برای محققین حوزههای پزشکی و علوم پایه پزشکیVaricella zoster virus in progressive forms of multiple sclerosi
Varicella zoster virus in progressive forms of multiple sclerosis
Objective: Methods: In the present study we analyzed the presence of VZV in patients wit progressive forms of MS; DNA from VZV was searched by real-time PCR in blood lymphocytes and in CSF of 20 patients with progressive MS. Ultrastructural study searching for viral particles in CSF was made with transmission electron microscopy.
Results: VZVDNAwas found in the CSF from 65% of cases with progressive MS- and VZV-like viral particles were found in 30% of these patients. Nonetheless, the amount of DNA and the number of viral particles were lower than those that have been found in MS patients with R/R at the time of relapse, but higher than those found during remission.
Conclusion: Similar to findings in patients with R/R MS, VZV might be associated to progressive MS, but in minor quantity. In these cases, the virus may produce a chronic, relentless infection or trigger a process of immune-mediated demyelination.
